MK-677

GH SECRETAGOGUE

• Molecular Formula: C27H36N4O5S
• Molecular Weight: 528.668 g/mol
• Sequence: Non-peptide

DESCRIPTION

MK-677 is a long active orally bioactive agonist of the GHS-R1a. As such, binds to the same receptor that GHRP2, GHRP6, and Ipamorelin also stimulate. Also called Ibutamoren, it has shown to cause a predictable rise in IGF-1 but unlike other GH secretagogues doesn’t help to decrease adipose tissue. It has been shown to increase lean muscle mass and might be a good candidate for sarcopenic patients with low bone mineral density. In order to reduce the negative effect of somatostatin, MK-677 is best taken on an empty stomach with no insulin in the system.

PROTOCOL

• Content & Potency:25mg capsules provided in quantities of 30.
• Suggested dosage:Take one capsule by mouth once daily on an empty stomach.

CLINICAL RESEARCH

Effects of an Oral Ghrelin Mimetic on Body Composition and ClinicalOutcomes in Healthy Older Adults A Randomized TrialRalf Nass, MD; Suzan S. Pezzoli, BA; Mary Clancy Oliveri, MS; James T. Patrie,MS; Frank E. Harrell Jr., PhD; Jody L. Clasey, PhD; Steven B. Heymsfield, MD;Mark A. Bach, MD; Mary Lee Vance, MD; and Michael O. Thorner, MB, BS, DSc

Background: Growth hormone secretion and muscle mass decline from midpuberty throughout life, culminating in sarcopenia, frailty, decreased function, and loss of independence. The decline of growth hormone in the development of sarcopenia is one of many factors, and its etiologic role needs to be demonstrated.

Objective: To determine whether MK-677, an oral ghrelin mimetic, increases growth hormone secretion into the young-adult range without serious adverse effects, prevents the decline of fat-free mass, and decreases abdominal visceral fat in healthy older adults.

Conclusion: Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated. Long-term functional and, ultimately, pharmacoeconomic, studies in elderly persons are indicated.

Here are some useful URLs where you can find information about MK-677:

1. The National Center for Biotechnology Information (NCBI) website offers a comprehensive overview of MK-677, including its chemical structure, pharmacology, and potential therapeutic applications: Link: https://pubchem.ncbi.nlm.nih.gov/compound/9939050
2. The National Library of Medicine’s PubMed database contains numerous research articles on MK-677, covering topics such as its effects on muscle mass, bone density, and cognitive function: Link: https://pubmed.ncbi.nlm.nih.gov/?term=MK-677

It is important to note that the use of MK-677 is not approved or regulated by any regulatory agency, and its safety and efficacy have not been fully studied. If you are considering using MK-677, it is important to consult a healthcare professional and carefully consider the potential risks and benefits.

MK-677 Research

However, I can provide you with some examples of studies that have been conducted on MK-677 and some resources where you can search for more information.

1. A 12-week study published in The Journal of Clinical Endocrinology & Metabolism found that MK-677 increased insulin-like growth factor 1 (IGF-1) and growth hormone levels in healthy older adults. (https://pubmed.ncbi.nlm.nih.gov/9467542/)
2. A study published in The Journal of Gerontology: Biological Sciences found that MK-677 improved body composition and bone density in older adults. (https://pubmed.ncbi.nlm.nih.gov/10737682/)
3. A 2-year study published in The Journal of Clinical Endocrinology & Metabolism found that MK-677 increased bone mineral density in older adults with osteoporosis. (https://pubmed.ncbi.nlm.nih.gov/12519876/)
4. A study published in The Journal of Clinical Endocrinology & Metabolism found that MK-677 improved growth hormone secretion and increased lean body mass in children with growth hormone deficiency. (https://pubmed.ncbi.nlm.nih.gov/12050226/)
5. A clinical trial published in The New England Journal of Medicine found that MK-677 increased muscle mass and improved physical function in older adults. (https://www.nejm.org/doi/full/10.1056/NEJMoa1709691)

Please note that the use of MK-677 is not approved by the FDA for any medical condition and that it is considered a research chemical, which means that it is not intended for human consumption. It is important to consult with a healthcare professional before using this or any other substance for any purpose.