ENCLOMIPHENE
AROMATASE INHIBITOR
- Molecular Formula : C26H28CINO
- Molecular Weight: 405.966 g/mol
- Peptide: Non-Peptide
DESCRIPTION
Enclomiphene is used in the process of treating male hypogonadism (lower function of the reproductive organs) and is a single isomer with pure estrogen antagonism. Enclomiphene is a non-steroidal selective estrogen receptor modulator (SERM) and acts by increasing gonadotropin secretion and gonadal production of testosterone. Enclomiphene has the potential to help the reproductive status in men and improve metabolic profiles. It is a single isoform of the more abundant clomiphene and has much fewer side effects.
PROTOCOL
- Content & Potency: 25mg capsules provided in a quantity of 30.
- Suggested dosage: Take one capsule by mouth once daily.
CLINICAL RESEARCH
Enclomiphene citrate stimulates testosterone production while preventingoligospermia: a randomized phase II clinical trial comparing topical testosterone.
Wiehle RD, Fontenot GK, Wike J, et al. ZA-203 Clinical Study Group. Fertil Steril.2014; 102(3): 720-727.
Objective: To determine the effect of enclomiphene citrate in men with secondary hypogonadism. Methods: iws randomized phase IIB study enrolled 124 men with a morning serum T level of <250 ng/dL on 2 occasions. e subjects were randomized to one of two doses of enclomiphene citrate (12.5-mg or 25-mg), 1% topical testosterone, or placebo. Hormone levels of LH, FSH, and T and seman level were measured before, during and aer 3 months of treatment.
Results: A total of 113 men received 3 months of treatment, and 73 completed the study and provided both baseline and at least 1 seman sample at the end of the study. All 3 active treatment groups showed significantly increased in total testosterone level from baseline compared with placebo, with no statistically significant difference in testosterone levels found between the active treatment groups compared with placebo.
ENCLOMIPHENE Research
Here are some examples of research studies that have been conducted on the peptide enclomiphene:
- A study on the safety and efficacy of enclomiphene in men with secondary hypogonadism: https://www.ncbi.nlm.nih.gov/pubmed/22785145
- A research article describing the potential use of enclomiphene for the treatment of male infertility: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414136/
- A study on the effects of enclomiphene on bone density in men with osteoporosis: https://www.ncbi.nlm.nih.gov/pubmed/27603205
- A review article on the pharmacology and therapeutic potential of enclomiphene: https://www.ncbi.nlm.nih.gov/pubmed/24304871
- A study on the effects of enclomiphene on insulin sensitivity in men with obesity and hypogonadism: https://www.ncbi.nlm.nih.gov/pubmed/30011067
Please note that this is not an exhaustive list and there may be other studies that have been conducted on enclomiphene.
POPULAR
Peptide pages
3-DESOXY DHEA
3-DESOXY DHEA Molecular Formula:R1=H, R2=CH3 Molecular Weight: 288.43 g/mol Sequence: Non-Peptide DESCRIPTION 3-Desoxy DHEA is a competitive aromatase inhibitor for use in controlling estrogen and
CJC 1295
CJC 1295 GROWTH HORMONE RELEASING Molecular Formula: C165H269N47O46 Molecular Weight: : 3647.15 Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-LeuLeu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 DESCRIPTION CJC 1295 stimulates growth hormone release via binding to the
DSIP
DSIP Molecular Formula : C35H48N10O15 Molecular Weight: 848.81 Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu DESCRIPTION DSIP is a well-known neuromodulator and natural somnogenic nonapeptide with many other physiological functions.