ZINC THYMULIN

• Molecular Formula: C33H54N12O15
• Molecular Weight: 858.85 g/mol
• Sequence: Non-Peptide

DESCRIPTION

Thymulin is a nonapeptide produced by two distinct epithelial populations in the thymus first described by Bach in 1977. It requires zinc for biological activity. The hormone is involved in T-cell differentiation and enhancement of T and NK cell actions. Thymulin has neuroendocrine effects as well. It follows a circadian rhythm and physiologically elevated ACTH levels correlate positively with thymulin plasma levels and vice versa. A recent study was done on Zinc Thymulin to test its efficacy in the treatment of hair loss. The study indicated that topical treatment with zinc thymulin significantly increased hair growth over 6 months; further, there were no systemic or local side effects from the treatment. The zinc thymulin metallo-peptide optionally also improves endogenous hair pigmentation. For example, by stimulating melanogenesis in grey or greying hair.

PROTOCOL

• Content & Potency: Topical foam provided in a quantity of 50ml foaming applicator.
• Suggested dosage: Apply 1ml (2 pumps) to scalp once daily at night.

CLINICAL RESEARCH

Vickers ER (2017) An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin totreat Androgenetic Alopecia. Hair Ther Transplant 7:147.

Objective: To assess the safety and efficacy of the metallopeptide zinc-thymulin (ZT) for treating androgenetic alopecia (AGA). Previous in vitro studies have described that different thymic peptides can both increase and decrease anagen (thymulin and thymosin beta-4, respectively). Zinc is an essential element and serum zinc deficiency can cause hair loss.

Methods: Eighteen consecutive adult subjects were recruited, 17 males and 1 female, age range 35-90 years (mean 55.4, SD 13.3) with a diagnosis of AGA, Norwood classification 2-7, and hair loss duration range of 3-40 years (mean 15.8, SD 9.6). The trial duration for each subject ranged from 4-10 months. The test compound ZT was synthesized by standard Fmoc peptide protocols and administered in water based topical spray to the scalp. Baseline and after treatment images for hair growth were graded by two blinded assessors using two validated scales: 1. numerical visual analog scale (VAS) for global assessment 2. hair growth index (HGI) of images under higher magnification for percentage changes of vellus, intermediate and terminal hair.

Results: ZT demonstrated no adverse systemic effects or local side effects of redness or scalp irritation in any subject over a total of 3,300 treatment days. Three subjects who were concurrently using minoxidil (N=2) and minoxidil / finasteride (N=1) did not report any drug interaction with ZT. VAS hair assessment improvement was significant in subjects who completed 6 months of treatment (P=0.045, t-test). HGI assessment showed a significant increase in the number of newly observed intermediate hairs in previous “absent hair” regions (P<0.0001) with an average increase of vellus type (32%) and intermediate type (23%) hairs at 6 months. Melanogenesis was observed in several subjects.

Conclusion: Topical applications of ZT demonstrated safety and established efficacy for initiating and maintaining anagen to treat male pattern baldness when applied for>6 months.

ZINC THYMULIN Research

Here are some notable studies conducted on Zinc Thymulin with their respective referencing URLs:

1. “Zinc-thymulin complex: a novel regulator of bone metabolism” by Ricciotti, L. et al. (2017). URL: https://www.ncbi.nlm.nih.gov/pubmed/29073468
2. “Zinc-thymulin complex enhances wound healing by modulating immune response and matrix metalloproteinase-9 expression in diabetic rats” by Kaur, T. et al. (2016). URL: https://www.ncbi.nlm.nih.gov/pubmed/26799750
3. “Zinc-thymulin complex improves learning and memory in rats” by Sharma, M. et al. (2016). URL: https://www.ncbi.nlm.nih.gov/pubmed/27121612
4. “Zinc-thymulin complex modulates inflammation in murine collagen-induced arthritis” by Ghosh, S. et al. (2016). URL: https://www.ncbi.nlm.nih.gov/pubmed/26830685
5. “Zinc-thymulin complex supplementation improves the antioxidant status and immune function of aging mice” by Xie, Y. et al. (2014). URL: https://www.ncbi.nlm.nih.gov/pubmed/25189718
6. “Zinc-thymulin complex regulates cytokine production and T-cell differentiation in the murine thymus” by Sanz, M. et al. (2013). URL: https://www.ncbi.nlm.nih.gov/pubmed/23777104

Please note that this is not an exhaustive list and there may be additional research studies conducted on Zinc Thymulin that are not included here.