Methylcobalamin

• Molecular Formula: C63H91CoN13O14P
• Molecular Weight: 1344.4 g/mol
• Sequence: Non-Peptide

DESCRIPTION

RG3 is a Panax ginseng that has been used in oriental countries for its pharmacologic effects, such as antidiabetic, neurological, and anti- inflammatory activities. Neuroinflammation is associated with activation of the central nervous system (CNS) glia with significant cytokine and chemokine production, infiltration of immune cells, edema, increased blood- brain barrier (BBB) permeability and breakdown. Ginsenoside 20(S) RG3 is one of the many active ingredients of ginseng saponins. RG3 is a ginseng known for aiding chronic inflammation. Specifically, RG3 has been shown to reduce chronic neurodegenerative inflammation, the proinflammatory cytokine, interleukin-6 (IL-6) and interleukin-1 β (IL-1 β ), and tumor necrosis factor- α (TNF- α ). Methylcobalamin and NAD+ are combined with RG3 to enhance its effects. Target treatments for RG3/Methylcobalamin/NAD+ include aging, traumatic brain injury (TBI), Alzheimer’s, diabetes, atherosclerosis, and hypertrophic scar formation. RG3 also has promising views for treatment in ovarian cancer, prostate cancer, and other cancers as well.

PROTOCOL

• Content & Potency: 2/2/50mg/mL provided in both a 15ml and 30 ml nasal spray applicator.
• Suggested dosage: Instill one spray intranasally 2-4 times daily.

CLINICAL RESEARCH

Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide- Induced Depression-Like Behavior and Neuroinflammation in Mice

Ginsenoside Rg3 (Rg3), a major active ingredient enriched in red ginseng, possess well-confirmed immunoregulatory effects. Immune disturbance is a common trigger and aggravating factor in depression. The aim of this study was to explore the effects on Rg3 on lipopolysaccharides (LPS)-induced depression-like behavior in mice and the involvement of immune regulation. Pretreatment with Rg3 (i.g., 20 and 40 mg/ kg) effectively ameliorated LPS (i.p., 0.83 mg/kg) induced body weight loss, anorexia, and immobility time in both the tail suspension test and the forced swimming test. Rg3 attenuated the disturbed turnover of tryptophan and serotonin in the hippocampus, accompanied by decreased mRNA expression of cytokines and indoleamine-2, 3- dioxygenase (IDO). These central benefits were partially linked to the regulation of microglia activation and nuclear factor kappa B (NF-kB) pathway. In addition, Rg3 significantly reduces LPS-induced elevation of interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α) in plasma, and restored the systemic balance of tryptophan-ky – nurenine metabolism. Taken together, our results demonstrated the Rg3 was effective in ameliorating depressive-like behavior induced by immune activation, adding new evidence to support its health benefits by immunoregulation.

Here are some useful URLs where you can find information about methylcobalamin:

1. The Office of Dietary Supplements at the National Institutes of Health (NIH) provides detailed information about vitamin B12, including methylcobalamin, its sources, recommended intake, and potential health benefits: https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
2. The National Library of Medicine’s PubMed database contains numerous research articles on methylcobalamin, covering topics such as its role in nerve function, its potential use as a therapeutic agent, and its interactions with other vitamins and minerals: https://pubmed.ncbi.nlm.nih.gov/?term=methylcobalamin
3. The Linus Pauling Institute at Oregon State University provides an in-depth overview of vitamin B12, including its various forms and their respective functions: https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12

These resources should provide a good starting point for anyone interested in learning more about methylcobalamin and its role in various biological processes.

Methylcobalamin Research

Methylcobalamin is a naturally occurring form of vitamin B12 that is involved in various physiological processes, including the metabolism of amino acids and fatty acids, DNA synthesis, and nerve function.

Here are a few examples of research studies involving Methylcobalamin:

1. Methylcobalamin promotes regeneration of injured peripheral nerves. https://www.ncbi.nlm.nih.gov/pubmed/16177488
2. Methylcobalamin improves cognitive function in patients with Alzheimer’s disease. https://www.ncbi.nlm.nih.gov/pubmed/26639041
3. Methylcobalamin relieves pain associated with diabetic neuropathy. https://www.ncbi.nlm.nih.gov/pubmed/12633527
4. Methylcobalamin improves sperm motility in infertile men. https://www.ncbi.nlm.nih.gov/pubmed/16965203
5. Methylcobalamin supplementation improves sleep quality in elderly individuals. https://www.ncbi.nlm.nih.gov/pubmed/25853308

It is important to note that the use of Methylcobalamin or any other supplement should be done under the guidance of a healthcare professional. Additionally, while Methylcobalamin has been shown to have potential health benefits, more research is needed to fully understand its effects on human health.