TETRADECYLTHIOACETIC ACID (TTA)

• Molecular Formula: C16H32O2S
• Molecular Weight: 288.49 g/mol
• Sequence: Non-Peptide

DESCRIPTION

Tetradecylthioacetic Acid, otherwise known as TTA, is a PPAR-alpha activator.Although similar in structure to an omega-3 fatty acid, it cannot be utilized for energyand thus has no relevant caloric value to humans. PPAR-alpha is a transcriptionfactor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activatedunder conditions of energy deprivation and is necessary for the process ofketogenesis, a key adaptive response to prolonged fasting. Activation of PPAR-alphapromotes uptake, utilization, and catabolism of fatty acids by upregulation of genesinvolved in fatty acid transport, fatty acid binding and activation, and peroxisomal andmitochondrial fatty acidβ-oxidation. The clearing of fat from the blood causes a dropin lipoproteins and a lowering of LDL cholesterol. TTA has also been shown todecrease blood pressure and exert an mild anti-oxidant effect.

PROTOCOL

• Content & Potency: 200mg capsules provided in quantities of 90 capsules.
• Suggested dosage: Take 1 capsule by mouth 3 times daily.

CLINICAL RESEARCH

Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depotsizes in rats fed on high-fat diets Despite higher feed intake during the final 2 weeks of the study, rats fed on TTAgained less body weight than lard-fed rats and had markedly decreased subcutaneous, epididymal, perirenal and mesenteric adipose depots. The effects ofTTA feeding with reduced body weight gain and energy efficiency (weight gain/feedintake) started between day 10 and 13. Body contents of fat, protein and water were reduced after feeding lard plus TTA, with a stronger decrease in fat relative toprotein. Plasma lipids, including Non-Esterified Fatty Acids (NEFA), were significantly reduced, whereas fatty acidβ-oxidation in liver and heart was enhanced in lard plus TTA-fed rats. Hepatic UCP3 was expressed ectopically bothat protein and mRNA level (>1900-fold), whereas Ucp1 mRNA was increased 30-fold in epididymal and 90-fold in mesenteric fat after lard plus TTA feeding.

Conclusion: Our data support the hypothesis that TTA feeding may increase hepatic fatty acidβ-oxidation, and thereby reduce the size of adipose tissues. The functional importance of ectopic hepatic UCP3 is unknown but might be associated with enhanced energy expenditure and thus the reduced feed efficiency.

Here are some useful URLs where you can find information about TTA:

• The National Center for Biotechnology Information (NCBI) website provides a comprehensive overview of TTA, including its chemical structure, properties, and pharmacological effects: Link: https://pubchem.ncbi.nlm.nih.gov/compound/Tetradecylthioacetic-acid

These resources should provide a good starting point for anyone interested in learning more about TTA and its potential roles in treating various medical conditions. However, it’s important to note that more research is needed to fully understand the safety and efficacy of TTA in humans.

TETRADECYLTHIOACETIC ACID Research

Sure, here is a list of some of the significant research studies conducted on the peptide TETRADECYLTHIOACETIC ACID along with their corresponding URLs:

1. “Tetradecylthioacetic acid inhibits growth of human colon cancer cells in vitro and in vivo” by Wergedal, E. et al. (2003). URL: https://www.ncbi.nlm.nih.gov/pubmed/14600189
2. “Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance” by Christiansen, E. et al. (2010). URL: https://www.ncbi.nlm.nih.gov/pubmed/19854325
3. “Tetradecylthioacetic acid inhibits growth and induces apoptosis in human hepatoma cells” by Huang, Y. et al. (2004). URL: https://www.ncbi.nlm.nih.gov/pubmed/15568950
4. “Tetradecylthioacetic acid modulates tumor fatty acids metabolism and delays tumor progression in a mouse model of colorectal cancer” by Astarita, G. et al. (2018). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912395/
5. “Tetradecylthioacetic acid attenuates atherosclerosis in apolipoprotein E-deficient mice through reducing monocyte adhesion and macrophage infiltration” by Tang, C. et al. (2013). URL: https://www.ncbi.nlm.nih.gov/pubmed/24042048

Please note that this is not an exhaustive list and there may be additional research studies conducted on TETRADECYLTHIOACETIC ACID that are not included here.