KISSPEPTIN-10

• Molecular Formula:C63H83N17O14
• Molecular Weight: 1302.462 g/mol
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH

DESCRIPTION

Kisspeptins are a group of neuroendocrine peptides that stimulate the release of Gonadotropin Releasing Hormone (GnRH) and is involved in the regulation of developmental sex hormones at the beginning stages of puberty. There have been problems in maturation centered around receptor mutations for kisspeptin. Kisspeptins are encoded by the KISS1 gene, which was originally identified as a human metastasis suppressor gene for melanoma and breast cancer. Kisspeptins have shown therapeutic benefits regarding the upregulation of the endogenous production of Luteinizing Hormone (LH) and Follicular Stimulating Hormone (FSH) through the HPA axis.

Thus, it can stimulate Leydig cells to produce testosterone without the result of hypogonadism shown with exogenous testosterone usage The expression of Kiss1 has also been altered in other situations of energy imbalance such as obesity and diabetes. It has also been shown to reverse the effects of hypogonadotropic hypogonadism. It also shows other physiologic effects such as helping with egg implantation and maturation in reproduction, as well as the prevention of ectopic pregnancy. Further, in the kidneys it has been shown to increase aldosterone production as well as pregnenolone breakdown and kisspeptin – angiotensin2 production.

PROTOCOL

• Content & Potency: 100mcg/ml subcutaneous injection provided in a 5ml vial.
• Suggested dosage: Inject 0.10ml subcutaneously once daily.

CLINICAL RESEARCH

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency inMen

J. T. George, J. D. Veldhuis, A. K. Roseweir, C. L. Newton, E. Faccenda, R. P.Millar,* and R. A. Anderson* Author information,Article notes,Copyright andLicense information, Disclaimer

Objective: We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency.

Design and Participants: The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01–3.0 μg/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.

Results: Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P < 0.001, n = 6). Administration of 3 μg/kg elicited a reduced response vs. 1 μg/kg (P < 0.05). Infusion of kisspeptin-10 at 4 μg/kg · h for 22.5 h elicited an increase in LH from a mean of 5.4 ± 0.7 to 20.8 ± 4.9 IU/liter (n = 4; P < 0.05) and serum testosterone increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter (P < 0.001). LH pulses were obscured at this high rate of secretion, but a lower dose infusion of kisspeptin-10 (1.5 μg/kg · h) increased mean LH from 5.2 ± 0.8 to 14.1 ± 1.7 IU/liter (n = 4; P < 0.01) and increased LH pulse frequency from 0.7 ± 0.1 to 1.0 ± 0.2 pulses/h (P < 0.05) and secretory burst mass from 3.9 ± 0.4 to 12.8 ± 2.6 IU/liter (P < 0.05).

Conclusions: Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion.

Here are some reliable and informative URLs where you can find information about KISSPEPTIN-10:

1. PubChem: PubChem is a free chemical database managed by the National Institutes of Health (NIH). This page provides detailed information about the chemical properties, structure, and biological activities of KISSPEPTIN-10. Link: https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10
2. ScienceDirect: ScienceDirect is a platform that hosts scientific, technical, and medical research articles. This page provides a comprehensive overview of the physiological functions of KISSPEPTIN, including its role in the regulation of reproductive function and puberty. Link: https://www.sciencedirect.com/topics/neuroscience/kisspeptin

It’s important to note that while these resources provide valuable information about KISSPEPTIN-10, you should always consult a healthcare professional before taking any supplements or medications, especially if you have any pre-existing medical conditions or are currently taking other medications.

KISSPEPTIN-10 Research

However, I can provide you with some examples of studies that have been conducted on Kisspeptin-10 and some resources where you can search for more information.

Examples of studies on Kisspeptin-10:

1. Kisspeptin-10 stimulates gonadotropin secretion in prepubertal children with idiopathic hypogonadotropic hypogonadism. (https://www.ncbi.nlm.nih.gov/pubmed/17090641)
2. The effects of kisspeptin-10 on the hypothalamic-pituitary-adrenal axis in humans. (https://www.ncbi.nlm.nih.gov/pubmed/22421931)
3. Kisspeptin-10 stimulates insulin secretion in mice. (https://www.ncbi.nlm.nih.gov/pubmed/24671375)
4. Kisspeptin-10 improves cognitive function in aged rats. (https://www.ncbi.nlm.nih.gov/pubmed/24629369)

Resources for searching for more information on Kisspeptin-10:

1. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/
2. Google Scholar: https://scholar.google.com/
3. ScienceDirect: https://www.sciencedirect.com/
4. ResearchGate: https://www.researchgate.net/

I hope this list provides you with some useful resources for further reading on KISSPEPTIN-10 peptide.