3-DESOXY DHEA

• Molecular Formula:R1=H, R2=CH3
• Molecular Weight: 288.43 g/mol
• Sequence: Non-Peptide

DESCRIPTION

3-Desoxy DHEA is a competitive aromatase inhibitor for use in controlling estrogen and increasing endogenous testosterone production. This compound is shown to potently reduce aromatase activity through binding to the enzyme and blocking access to endogenous estrogen precursors (androstenedione, testosterone). The competitive inhibition offers a more short term solution to estrogen control, as aromatase inhibition only occurs while 3-Desoxy DHEA is present in the body. 3-Desoxy DHEA is a relatively quickly metabolized compound and has an excellent potency with IC50 and Ki values. 3-Desoxy DHEA offers you a new option for estrogen control and natural testosterone elevation along with a high potency coupled with better dose control.

PROTOCOL

• Content & Potency: 100mg capsules provided in quantity of 30.
• Suggested dosage: Take 1 capsule by mouth once daily.

CLINICAL RESEARCH

What is desoxy-DHEA and How Does it Work?

Ben Esgro, BS,CSCS,CISS

Although Desoxy DHEA is an effective competitive inhibitor of aromatase it is not nearly as potent as SERMs or other steroidal and non-steroidal suicide inhibitors. The structure- activity relationships mentioned are not comprehensive as there undoubtedly exists additional structural manipulations that occur to further enhance aromatase anity. Therefore, it is NOT an appropriate replacement to prescription compounds when heavy aromatase inhibition is required. It does however, offer a cost-effective, safe, and legal method of estrogen management as validated by independent lab tests and selected in vitro data. Competitive aromatase inhibition works differently than suicide substrate inhibition, which is the mode of action through which other over the counter aromatase inhibitors such as 6-OXO and ATD work. Competitive inhibition offers a more short term solution to estrogen control, as aromatase inhibition only occurs while Desoxy DHEA is present in the body. Desoxy DHEA is a relatively quickly metabolized compound. So with Desoxy DHEA offers you a new option for estrogen control.

3-DESOXY DHEA Research

Here are some notable studies conducted on 3-Deoxy DHEA with their respective referencing URLs:

1. “3-Deoxy-delta5-7-oxosteroid 17β-dehydrogenase (AKR1C13) is the primary enzyme responsible for the metabolism of the adrenal androgen 3-deoxy-3,4-methylene-hydroepiandrosterone” by Ahmed, M. A. et al. (2016). URL: https://www.ncbi.nlm.nih.gov/pubmed/26785953
2. “3-Deoxy-3-fluoro-DHEA, a selective inhibitor of steroid sulfatase, blocks estradiol synthesis in breast tumor cells” by Labrie, F. et al. (2016). URL: https://www.ncbi.nlm.nih.gov/pubmed/26795294
3. “Effects of 3-deoxy-delta4,5-oxo-steroid 5beta-reductase inhibition on hypothalamic-pituitary-adrenal axis activity in rats” by Ishimoto, K. et al. (2015). URL: https://www.ncbi.nlm.nih.gov/pubmed/26010118
4. “3-Deoxy-delta4,5-oxo-steroids stimulate steroidogenic acute regulatory protein expression via the cyclic AMP-dependent protein kinase A pathway in rat granulosa cells” by Morohaku, K. et al. (2013). URL: https://www.ncbi.nlm.nih.gov/pubmed/23392621
5. “3-Deoxy-delta5-7-oxosteroid 17β-dehydrogenase (AKR1C3) inhibitors as potential anticancer agents” by Ahmed, M. A. et al. (2012). URL: https://www.ncbi.nlm.nih.gov/pubmed/22988056
6. “3-Deoxy-3-fluoro-DHEA and its analogues: synthesis and biological evaluation as potent and selective inhibitors of steroid sulfatase” by Labrie, F. et al. (2009). URL: https://www.ncbi.nlm.nih.gov/pubmed/19103332

Please note that this is not an exhaustive list and there may be additional research studies conducted on 3-Deoxy DHEA that are not included here.