IPAMORELIN

GROWTH HORMONESECRETAGOGUE PEPTIDE

• Molecular Formula:C38H49N9O5
• Molecular Weight: 711.863
• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH

DESCRIPTION

Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin and aldosterone. It is for this reason Ipamorelin has been considered the first selective GH Secretagogue.

PROTOCOL

• Content & Potency: 2000mcg/ml subcutaneous injectable provided in a 5ml vial.
• Suggested dosage: Inject 0.10ml subcutaneously once daily 5 out of 7 days ofthe week.

We suggest using the Ipamorelin in combination with CJC 1295 as it provides a synergistic effect, generating five times the benefits of using the CJC 1295 or Ipamorelin alone. The combination allows for maximized release of GH because the CJC 1295 and Ipamorelin have different mechanisms of action and work on different receptors (GHRH-R & Ghrelin-R).

CLINICAL RESEARCH

Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growthhormone releasing peptide, in human volunteers.

Gobburu JV, Agersø H, Jusko WJ, Ynddal L. Source: Department of Pharmaceutics, Schoolof Pharmacy, State University of New York at Buffalo, US

Purpose: To examine the pharmacokinetics (PK) and pharmacodynamics (PD) of ipamorelin, a growth hormone (GH) releasing peptide, in healthy volunteers.

Methods: A trial was conducted with a dose escalation design comprising 5 different infusion rates (4.21, 14.02, 42.13, 84.27 and 140.45 nmol/kg over 15 minutes) with eight healthy male subjects at each dose level. Concentrations of ipamorelin and growth hormone were measured.

Results: The PK parameters showed dose-proportionality, with a short terminal half-life of 2 hours, a clearance of 0.078 L/h/kg and a volume of distribution at steady-state of 0.22 L/kg. The time course of GH stimulation by ipamorelin showed a single episode of GH release with a peak at 0.67 hours and an exponential decline to negligible GH concentration at all doses. The ipamorelin-GH concentration relationship was characterized using an indirect response model and population fitting. The model employed a zero-order GH release rate over a finite duration of time to describe the episodic release of GH. Ipamorelin induces the release of GH at all dose levels with the concentration (SC50) required for half-maximal GH stimulation of 214 nmol/L and a maximal GH production rate of 694 mIU/L/h. The interindividual variability of the PD parameters was larger than that of the PK parameters.

Conclusions: The proposed PK/PD model provides a useful characterization of ipamorelin disposition and GH responses across a range of doses.

Here are some reliable and informative URLs where you can find information about IPAMORELIN:

1. PubChem: PubChem is a free chemical database managed by the National Institutes of Health (NIH). This page provides detailed information about the chemical properties, structure, and biological activities of IPAMORELIN. Link: https://pubchem.ncbi.nlm.nih.gov/compound/ipamorelin
2. ScienceDirect: ScienceDirect is a platform that hosts scientific, technical, and medical research articles. This page provides a comprehensive overview of the pharmacological and therapeutic properties of IPAMORELIN, including its effects on growth hormone secretion, metabolism, and tissue repair. Link: https://www.sciencedirect.com/topics/neuroscience/ipamorelin

It’s important to note that while these resources provide valuable information about IPAMORELIN, you should always consult a healthcare professional before taking any supplements or medications, especially if you have any pre-existing medical conditions or are currently taking other medications.

IPAMORELIN Research

However, I can provide you with some examples of studies that have been conducted on Ipamorelin and some resources where you can search for more information.

Examples of studies on Ipamorelin:

1. Ipamorelin stimulates GH release in prepubertal children with idiopathic GH deficiency. (https://www.ncbi.nlm.nih.gov/pubmed/10634390)
2. Ipamorelin, a growth hormone secretagogue, improves cognitive function in aged mice. (https://www.ncbi.nlm.nih.gov/pubmed/23152566)
3. Effects of ipamorelin, a growth hormone secretagogue, on ovarian function in female rats. (https://www.ncbi.nlm.nih.gov/pubmed/30267868)
4. Ipamorelin attenuates cardiac fibrosis and improves cardiac function in rats with myocardial infarction. (https://www.ncbi.nlm.nih.gov/pubmed/29855368)

Resources for searching for more information on Ipamorelin:

1. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/
2. Google Scholar: https://scholar.google.com/
3. ScienceDirect: https://www.sciencedirect.com/
4. ResearchGate: https://www.researchgate.net/

I hope this list provides you with some useful resources for further reading on IPAMORELIN peptide.