Glycyrrhetinic Acid

• Molecular Formula: C30H46O4
• Molecular Weight: 420.43 g/mol
• Sequence: Non-Peptide

DESCRIPTION

Aminophylline and glycyrrhetinic acid transdermal cream is used for fat loss. Aminophylline and glycyrrhetinic prevent cAMP breakdown. Cyclic AMP (cAMP) functions in several biochemical processes including the regulation of glycogen, sugar, and lipid metabolism. cAMP works by activating protein kinase A (PKA) which assists in glycogen, sugar, and lipid metabolism. Aminophylline has displayed topical fat reduction from the waist. In a study examining aminophylline cream application, the reduction in waist circumference was significant for both men and women. Over a period of 12 weeks, participants in the study lost 11cm in waist circumference. In differentiated adipocytes, 18 β -glycyrrhetinic acid increases the level of glycerol release and up-regulates the mRNA of hormone-sensitive lipase, adipose triglyceride lipase, and perilipin, as well as the phosphorylation of hormone-sensitive lipase. 18 β- glycyrrhetinic acid alters fat mass by directly affecting adipogenesis in maturing preadipocytes and lipolysis in mature adipocytes. Therefore, aminophylline and 18 β- glycyrrhetinic acid may be useful for treating obesity. Both aminophylline and glycyrrhetinic acid combined effectively combat fat loss. Aminophylline and glycyrrhetinic acid fat loss cream yields the best results through topical application.

PROTOCOL

• Content & Potency: Aminophylline/Glycyrrhetinic Acid 0.5%/2.5% transdermal cream provided ina 60ml Topiclick cream applicator.
• Suggested dosage: Apply 1ml twice daily transdermally.

CLINICAL RESEARCH

18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis

18 β -Glycyrrhetinic acid (18 β -GA) obtained from the herb liquorice has various pharmacological properties including anti-inflammatory and anti-bacterial activities. However, potential biological anti-obesity activities are unclear. In this study, novel biological activities of 18 β -GA in the adipogenesis of 3T3-L1 preadipocytes and in lipolysis of differentiated adipocytes were identified. Mouse 3T3-L1 cells were used as an in vitro model of adipogenesis and lipolysis, using a mixture of insulin/dexamethsone/3- isobutyl-1-methylxanthine (IBMX) to induce differentiation.

The amount of lipid droplet accumulation was determined by an AdipoRed assay. The expression of several adipogenic transcription factors and enzymes was investigated using real-time reverse transcriptase- polymerase chain reaction (RT-PCR) and Western blotting. 18 β -GA dose-dependently (1–40 lM) significantly decreased lipid accumulation in maturing preadipocytes. In 3T3-L1 preadipocytes, 10 lM of 18 β -GA down-regulated the transcriptional levels of peroxisome proliferator-activated receptor c, CCAAT/enhancer-binding protein and adiponectin, which are markers of adipogenic differentiation via Akt phosphorylation. Also, in differentiated adipocytes, 18 β -GA increased the level of glycerol release and up-regulated the mRNA of hor – mone-sensitive lipase, adipose TG lipase and perilipin, as well as the phosphorylation of hormone-sensitive lipase at Serine 563. The results indicate that 18 β -GA alters fat mass by directly affecting adipogenesis in maturing preadipocytes and lipolysis in matured adipocytes. Thus, 18 β -GA may be useful for the treatment of obesity.

Here are some reliable and informative URLs where you can find information about Glycyrrhetinic Acid:

1. PubChem: PubChem is a free chemical database managed by the National Institutes of Health (NIH). This page provides detailed information about the chemical properties, structure, and biological activities of Glycyrrhetinic Acid. Link: https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhetinic-acid
2. ScienceDirect: ScienceDirect is a platform that hosts scientific, technical, and medical research articles. This page provides a comprehensive overview of the pharmacological and therapeutic properties of Glycyrrhetinic Acid, including its anti-inflammatory, anticancer, and antiviral effects. Link: https://www.sciencedirect.com/topics/neuroscience/glycyrrhetinic-acid
3. NCBI: The National Center for Biotechnology Information (NCBI) is a part of the National Institutes of Health (NIH). This research article provides a detailed review of the pharmacological and clinical properties of Glycyrrhetinic Acid and its potential therapeutic applications. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973990/

It’s important to note that while these resources provide valuable information about Glycyrrhetinic Acid, you should always consult a healthcare professional before taking any supplements or medications, especially if you have any pre-existing medical conditions or are currently taking other medications.

Glycyrrhetinic Acid Research

Sure, here is a list of some of the significant research studies conducted on the peptide Glycyrrhetinic Acid along with their corresponding URLs:

1. “Glycyrrhetinic acid and its derivatives as potential therapeutic agents for chronic diseases: An overview of the key findings” (2021) – This review article highlights the therapeutic potential of GA and its derivatives in the management of various chronic diseases such as cancer, inflammation, and diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8038349/
2. “Glycyrrhetinic acid and its derivatives: anti-cancer activities and molecular mechanisms” (2018) – This study explores the potential of GA and its derivatives as anti-cancer agents and their underlying molecular mechanisms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127987/
3. “Glycyrrhetinic acid, a natural triterpenoid, induces apoptosis and autophagy in human cervical cancer cells” (2020) – This study investigates the anti-cancer activity of GA on cervical cancer cells and its underlying mechanisms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079329/
4. “Glycyrrhetinic acid modulates the TLR4/NF-κB signaling pathway in lipopolysaccharide-induced mastitis in mice” (2021) – This study investigates the anti-inflammatory activity of GA in a mouse model of mastitis and its mechanism of action. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959804/
5. “Glycyrrhetinic acid attenuates diabetic cardiomyopathy through inhibition of oxidative stress and inflammation via PI3K/Akt signaling pathway” (2021) – This study investigates the potential of GA in the management of diabetic cardiomyopathy and its underlying mechanisms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908089/

I hope this list provides you with some useful resources for further reading on Glycyrrhetinic Acid. Please note that there may be more recent studies published that are not included in this list.