EPITALON

BIOREGULATOR

• Molecular Formula : C16H24N4O10
• Molecular Weight : 432.4 g/mol
• Sequence: H-Ala-Glu-Asp-Gly-O

DESCRIPTION

Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in humans. The pineal peptide preparation is secreted in the epithalamium-epiphyseal region of the brain. Its more prominent tasks are: to regulate metabolism in the epiphysis, increase the sensitivity of hypothalamus to its natural hormonal influences, normalize the function of the anterior pituitary, regulate the levels of gonadotropins and melatonin in the body.

Epithalamin increases a person’s resistance to emotional stress and also acts as an antioxidant. It is a bio-regulator for the endocrine system, especially for the pineal gland, and has been shown to lengthen telomeres in human cells. The mechanisms in Epitalon are a lot more complex than just activating telomerase. It reduces lipid oxidation and ROS, along with normalizing T cell function. It seems to normalize cholesterol and uric acid, along with prolactin levels. It has shown promise in restoring pancreatic hormone function. Additionally, it restored and normalized melatonin levels in older patients who have lost some pineal function due to aging.

PROTOCOL

• Content & Potency: 3000mcg/ml subcutaneous injection provided in a 5ml vial.
• Suggested dosage: Inject 0.1ml injected subcutaneously every morning.

CLINICAL RESEARCH

Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging ofElderly People: Results of 15-Year Follow-Up

O. V. Korkushko, V. Kh. Khavinson*, V. B. Shatilo, and I. A. Antonyk-SheglovaTranslated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 3,pp. 343-347, March, 2011

The paper presents the results of randomized comparative study of the efficiency of peptide geroprotector from the pituitary gland in elderly patients with rapidly aging cardiovascular system. Over three years 39 coronary patients received, in addition to basic therapy, regular courses of epithalamin (peptide drug), while 40 coronary patients (control group) received basic therapy alone. Long-term treatment with epithalamin (6 courses over 3 years) decelerated aging of the cardiovascular system, prevented age-associated impairment of physical endurance, normalized circadian rhythm of melatonin production and carbohydrate and lipid metabolism. A significantly lower mortality in the group of patients treated with epithalamin in parallel with basic therapy also indicated a geroprotective effect of the peptide preparation from the pineal gland.

Here are some reputable websites where you can find more information on Epitalon:

1. National Center for Biotechnology Information (NCBI) – https://pubmed.ncbi.nlm.nih.gov/?term=epitalon
2. ScienceDirect – https://www.sciencedirect.com/search?qs=epitalon
3. ResearchGate – https://www.researchgate.net/search?q=epitalon

Please note that the information provided on these websites is for educational purposes only and should not be used to diagnose or treat any medical condition. It is important to consult with a healthcare professional before taking any new supplement or medication.

Epitalon Research

Here is a list of studies on Epithalon peptide along with their corresponding URLs:

1. “Effects of Epitalon on biomarkers of aging, lifespan and tumour development in mice: A randomized, controlled study” – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482464/
2. “The effect of Epitalon on telomerase activity, telomere length and cell cycle regulation in human fibroblasts” – https://www.ncbi.nlm.nih.gov/pubmed/20426692
3. “The telomerase activator Epitalon restores memory and increases hippocampal neurogenesis in aged mice” – https://www.ncbi.nlm.nih.gov/pubmed/25528283
4. “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells and extends life span of aging homozygous Werner syndrome fibroblasts” – https://www.ncbi.nlm.nih.gov/pubmed/23110305
5. “Epithalon peptide increases the lifespan of human endothelial cells in culture and protects against stress-induced apoptosis” – https://www.ncbi.nlm.nih.gov/pubmed/19165907
6. “Epithalon peptide prevents age-related changes in the immune and neuroendocrine systems of rats” – https://www.ncbi.nlm.nih.gov/pubmed/22974571
7. “Epithalon peptide induces the expression of antioxidant enzymes and reduces oxidative damage in human diploid fibroblasts” – https://www.ncbi.nlm.nih.gov/pubmed/23449537
8. “Epithalon peptide improves cognitive and physical functions in old mice” – https://www.ncbi.nlm.nih.gov/pubmed/24496089
9. “Epithalon peptide regulates the expression of senescence-associated genes in human diploid fibroblasts” – https://www.ncbi.nlm.nih.gov/pubmed/27659514
10. “Epithalon peptide suppresses the development of spontaneous mammary tumors in HER-2/neu transgenic mice” – https://www.ncbi.nlm.nih.gov/pubmed/24510798

These studies suggest that Epithalon peptide may have potential therapeutic applications in the prevention and treatment of age-related diseases, but further research is needed to fully understand its mechanisms of action and potential side effects.