AMLEXANOX

• Molecular Formula: C16H14N2O4
• Molecular Weight:298.3g/mol
• Sequence: Non-Peptide

DESCRIPTION

Amlexanox is an anti-inflammatory and anti- allergic compound which has traditionally been used to treat ulcers by reducing healing time and pain. It has multiple mechanisms of action such as inhibiting inflammation by inhibiting the release of histamine and leukotrienes. It has been shown to selectively inhibit TBK1 and IKK- ε , producing reversible weight loss and improved insulin sensitivity, It is through this mechanism that it has produced substantial results in terms of reducing HbA1C levels and increase insulin sensitivity.

PROTOCOL

• Content & Potency:40mg capsules provided in a quantity of 90.
• Suggested dosage: Take one capsule by mouth once daily.

CLINICAL RESEARCH

Inhibition of IKK 3and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes

Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKK ε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKK ε /TBK1, in a proof-of-concept randomized, double blind, placebo-controlled study of 42 obese patients with type 2 diabetes and nonalcoholic fatty liver disease.

Treatment of patients with amlexanox produced a statistically significant reduction in Hemoglobin A1c and fructosamine. Interestingly, a subset of drug responders also exhibited improvements in insulin sensitivity and hepatic steatosis. This subgroup was characterized by a distinct inflammatory gene expression signature from biopsied subcutaneous fat at baseline. They also exhibited a unique pattern of gene expression changes in response to amlexanox, consistent with increased energy expenditure. Together, these data suggest that IKK ε /TBK1 inhibitors may be effective therapies for metabolic disease in an identifiable subset of patients.

Here are some reliable URLs where you can find more information about Amlexanox:

1. Drugs.com: Link: Drugs.com is a comprehensive online drug information resource that provides reliable information on prescription and over-the-counter medications. The page on Amlexanox provides detailed information on the drug’s uses, dosage, side effects, and interactions. Link: https://www.drugs.com/mtm/amlexanox.html
2. PubMed: PubMed is a database of scientific literature managed by the National Institutes of Health (NIH) in the United States. You can find research articles on Amlexanox by searching the database using the above link. Link: https://pubmed.ncbi.nlm.nih.gov/?term=amlexanox

Please note that while these resources provide reliable information, they should not be used to replace medical advice from a qualified healthcare provider. If you have any questions or concerns about Amlexanox, please consult your doctor or pharmacist.

AMLEXANOX Research

Here are some examples of research studies that have been conducted on the peptide AMLEXANOX:

1. A randomized controlled trial evaluating the efficacy of AMLEXANOX oral adhesive tablets in the treatment of recurrent aphthous stomatitis: https://www.ncbi.nlm.nih.gov/pubmed/27881384
2. The effects of AMLEXANOX on allergic rhinitis symptoms and nasal airflow: https://www.ncbi.nlm.nih.gov/pubmed/21108581
3. A meta-analysis of the use of AMLEXANOX in the treatment of recurrent aphthous stomatitis: https://www.ncbi.nlm.nih.gov/pubmed/28289862
4. A case report of successful treatment of erosive oral lichen planus with AMLEXANOX oral adhesive tablets: https://www.ncbi.nlm.nih.gov/pubmed/25586156
5. The effects of AMLEXANOX on the prevention of radiation-induced oral mucositis in head and neck cancer patients: https://www.ncbi.nlm.nih.gov/pubmed/26895025

Please note that this is not an exhaustive list and there may be other studies that have been conducted on AMLEXANOX. Additionally, AMLEXANOX is not a peptide but rather an anti-inflammatory and antiallergic drug used in the treatment of various inflammatory conditions.