DSIP

• Molecular Formula : C35H48N10O15
• Molecular Weight: 848.81
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

DESCRIPTION

DSIP is a well-known neuromodulator and natural somnogenic nonapeptide with many other physiological functions. It is typically found in the brain and easily passes the blood-brain barrier. It is mainly prescribed for the treatment of pain conditions, alcohol and opioid withdrawal, CRH and stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti- oncogenic protein. It has been discovered and heavily studied for over 40 years, yet, the mechanism of action is still complex and not well understood. The results of studies of DSIP and its analogues over a period of 30 years since its discovery enable one to state with confidence that DSIP is a unique member of the family of peptide neuromodulators.

It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to a variety of stresses. Some of the effects of the peptide are accomplished through the modulating action on central regulatory processes, owing to the systemic antioxidant action, the modulating influence on the activity of GABAergic, glutamatergic, and other neuronal systems. It also works on the expression of early response genes in brain structures, and on the activity of biosynthetic and proteolytic processes. DSIP has traditionally been dosed as an IV infusion, however, it can be given subcutaneously as well. Traditional doses have been 100mcg.

PROTOCOL

• Content & Potency: 1000mcg/ml subcutaneous injectable provided in a 3ml vial.
• Suggested dosage: Inject 0.1ml subcutaneously once daily at bedtime.

CLINICAL RESEARCH

In several species DSIP at low doses has been shown to promote sleep. Although its physiological role remains to be clarified, DSIP illustrates several concepts applicable to other brain peptides. These include the bell- shaped dose- response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form. Concepts applicable to one neuropeptide, therefore, appear to be applicable to others. In this article Abba Kastin and colleagues review the known effects of DSIP and argue that more work needs to be carried out before it can be labelled functionally.

Here are some reliable sources that provide information on DSIP:

1. ScienceDirect: ScienceDirect is a database of scientific research articles and book chapters. It includes articles on DSIP, including its effects on sleep and other physiological processes. Link: https://www.sciencedirect.com/topics/medicine-and-dentistry/delta-sleep-inducing-peptide
2. Wikipedia: Wikipedia is a general encyclopedia that includes an article on DSIP. While Wikipedia articles should be used with caution and verified with other sources, it can provide a useful overview of the compound and its properties. Link: https://en.wikipedia.org/wiki/Delta_sleep-inducing_peptide

It’s important to note that while these sources can provide helpful information on DSIP, they are intended for scientific and medical professionals and may contain technical terms and jargon. If you have specific questions or concerns about DSIP or any other peptide hormones, it’s best to consult with a qualified healthcare provider or medical expert.

DSIP Research